Assay Detail
Functional
CHEMBL933320
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Inhibition of LPS-induced TNFalpha production in human THP1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.41 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.89 |
| CHEMBL10 | SB-203580 | — | 1 | 7.80 |
| CHEMBL255410 | — | — | 1 | 7.64 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 7.41 |
| CHEMBL404887 | — | — | 1 | 6.66 |
| CHEMBL255153 | — | — | 1 | 6.47 |
| CHEMBL270617 | — | — | 1 | 6.36 |
| CHEMBL404722 | — | — | 1 | 6.36 |
| CHEMBL255613 | — | — | 1 | 6.36 |
| CHEMBL270614 | — | — | 1 | 6.35 |
| CHEMBL255972 | — | — | 1 | 6.01 |
| CHEMBL401704 | — | — | 1 | 5.85 |
| CHEMBL429254 | — | — | 1 | 5.82 |
| CHEMBL270405 | — | — | 1 | 5.82 |
| CHEMBL257519 | — | — | 1 | 5.82 |
| CHEMBL257041 | — | — | 1 | 5.68 |
| CHEMBL255411 | — | — | 1 | 5.58 |
| CHEMBL401984 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL10 | SB-203580 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL255410 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL404887 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL255153 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL270617 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL404722 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL255613 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL270614 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL255972 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL401704 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL429254 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270405 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL257519 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL257041 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL255411 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL401984 | — | IC50 | = | 2900.0 | nM | 5.54 |