Assay Detail
Binding
CHEMBL933757
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Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.35 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254586 | — | — | 1 | 6.56 |
| CHEMBL402207 | — | — | 1 | 6.44 |
| CHEMBL403773 | — | — | 1 | 6.06 |
| CHEMBL59898 | — | — | 1 | 5.96 |
| CHEMBL402282 | — | — | 1 | 5.64 |
| CHEMBL1529 | DIPHENIDOL HYDROCHLORIDE | 4.0 | 1 | 5.55 |
| CHEMBL257174 | — | — | 1 | 5.40 |
| CHEMBL257804 | — | — | 1 | 5.36 |
| CHEMBL256923 | — | — | 1 | 5.26 |
| CHEMBL258385 | — | — | 1 | 5.14 |
| CHEMBL403592 | — | — | 1 | 4.92 |
| CHEMBL436850 | — | — | 1 | 4.63 |
| CHEMBL257547 | — | — | 1 | 4.59 |
| CHEMBL258161 | — | — | 1 | 4.45 |
| CHEMBL257586 | — | — | 1 | 4.32 |
| CHEMBL255692 | — | — | 1 | - |
| CHEMBL404866 | — | — | 1 | - |
| CHEMBL403029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254586 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL402207 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL403773 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL59898 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL402282 | — | Ki | = | 2290.87 | nM | 5.64 |
| CHEMBL1529 | DIPHENIDOL HYDROCHLORIDE | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL257174 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL257804 | — | Ki | = | 4365.16 | nM | 5.36 |
| CHEMBL256923 | — | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL258385 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL403592 | — | Ki | = | 12022.64 | nM | 4.92 |
| CHEMBL436850 | — | Ki | = | 23442.29 | nM | 4.63 |
| CHEMBL257547 | — | Ki | = | 25703.96 | nM | 4.59 |
| CHEMBL258161 | — | Ki | = | 35481.34 | nM | 4.45 |
| CHEMBL257586 | — | Ki | = | 47863.01 | nM | 4.32 |
| CHEMBL255692 | — | Ki | = | 213796.21 | nM | - |
| CHEMBL404866 | — | Ki | = | 177827.94 | nM | - |
| CHEMBL403029 | — | Ki | = | 457088.19 | nM | - |