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Compound Detail

CHEMBL258385

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Cl.Cl.OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL258385
Phase Preclinical
Structure Type MOL
InChI Key JOZKTPSVXOGLJA-UHFFFAOYSA-N
Parent Compound CHEMBL1182652
Active Moiety CHEMBL1182652
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

310.4
MW (Da)
2.61
ALogP
3
HBA
2
HBD
35.5
PSA (Ų)
0.86
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H28Cl2N2O
MW 383.36
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.56

Activity Summary

Ki 5 meas. best 6.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 6.22 6.22 602.6 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 6.18 6.18 660.7 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 5.93 5.93 1174.9 1
Muscarinic acetylcholine receptor M5
CHEMBL2035
Ki 5.85 5.85 1412.5 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 5.14 5.14 7244.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18395442 10.1016/j.bmcl.2008.03.061 Muscarinic acetylcholine receptor M1 1
18395442 10.1016/j.bmcl.2008.03.061 Muscarinic acetylcholine receptor M2 1
18395442 10.1016/j.bmcl.2008.03.061 Muscarinic acetylcholine receptor M3 1
18395442 10.1016/j.bmcl.2008.03.061 Muscarinic acetylcholine receptor M4 1
18395442 10.1016/j.bmcl.2008.03.061 Muscarinic acetylcholine receptor M5 1

Data from ChEMBL 36 via Core Engine