Assay Detail
Binding
CHEMBL933758
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Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.43 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254586 | — | — | 1 | 6.56 |
| CHEMBL402207 | — | — | 1 | 6.43 |
| CHEMBL258385 | — | — | 1 | 6.18 |
| CHEMBL59898 | — | — | 1 | 6.14 |
| CHEMBL403773 | — | — | 1 | 6.14 |
| CHEMBL1529 | DIPHENIDOL HYDROCHLORIDE | 4.0 | 1 | 5.95 |
| CHEMBL256923 | — | — | 1 | 5.76 |
| CHEMBL257804 | — | — | 1 | 5.44 |
| CHEMBL436850 | — | — | 1 | 5.39 |
| CHEMBL257174 | — | — | 1 | 5.28 |
| CHEMBL402282 | — | — | 1 | 5.26 |
| CHEMBL258161 | — | — | 1 | 5.13 |
| CHEMBL257547 | — | — | 1 | 5.12 |
| CHEMBL403592 | — | — | 1 | 4.91 |
| CHEMBL257586 | — | — | 1 | 4.36 |
| CHEMBL403029 | — | — | 1 | 4.15 |
| CHEMBL404866 | — | — | 1 | 4.06 |
| CHEMBL255692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254586 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL402207 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL258385 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL59898 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL403773 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL1529 | DIPHENIDOL HYDROCHLORIDE | Ki | = | 1122.02 | nM | 5.95 |
| CHEMBL256923 | — | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL257804 | — | Ki | = | 3630.78 | nM | 5.44 |
| CHEMBL436850 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL257174 | — | Ki | = | 5248.07 | nM | 5.28 |
| CHEMBL402282 | — | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL258161 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL257547 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL403592 | — | Ki | = | 12302.69 | nM | 4.91 |
| CHEMBL257586 | — | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL403029 | — | Ki | = | 70794.58 | nM | 4.15 |
| CHEMBL404866 | — | Ki | = | 87096.36 | nM | 4.06 |
| CHEMBL255692 | — | Ki | = | 380189.4 | nM | - |