Assay Detail
Functional
CHEMBL933780
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Antiinflammatory activity in human neutrophils assessed as inhibition of formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.59 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21396 | SKIMMIANINE | — | 1 | 4.72 |
| CHEMBL255459 | — | — | 1 | 4.54 |
| CHEMBL258230 | AVICENNOL | — | 1 | 4.50 |
| CHEMBL402862 | ROBUSTINE | — | 1 | - |
| CHEMBL402653 | — | — | 1 | - |
| CHEMBL252925 | GAMMA-FAGARINE | — | 1 | - |
| CHEMBL256113 | AVICENNOL METHYL ETHER | — | 1 | - |
| CHEMBL253551 | FRAXIDIN METHYL ETHER | — | 1 | - |
| CHEMBL325864 | SCOPARONE | — | 1 | - |
| CHEMBL256915 | CLEOMISCOSIN D | — | 1 | - |
| CHEMBL404050 | — | — | 1 | - |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | - |
| CHEMBL256497 | EDULITINE | — | 1 | - |
| CHEMBL255298 | — | — | 1 | - |
| CHEMBL402069 | — | — | 1 | - |
| CHEMBL509839 | ISODICTAMNINE | — | 1 | - |
| CHEMBL22533 | DICTAMNINE | — | 1 | - |
| CHEMBL254379 | LUVANGETIN | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL438883 | — | — | 1 | - |
| CHEMBL256536 | — | — | 1 | - |
| CHEMBL255299 | — | — | 1 | - |
| CHEMBL274512 | — | — | 1 | - |
| CHEMBL403946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21396 | SKIMMIANINE | IC50 | = | 19150.0 | nM | 4.72 |
| CHEMBL255459 | — | IC50 | = | 28930.0 | nM | 4.54 |
| CHEMBL258230 | AVICENNOL | IC50 | = | 32020.0 | nM | 4.50 |
| CHEMBL402862 | ROBUSTINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL402653 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL252925 | GAMMA-FAGARINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL256113 | AVICENNOL METHYL ETHER | IC50 | > | 50000.0 | nM | - |
| CHEMBL253551 | FRAXIDIN METHYL ETHER | IC50 | > | 50000.0 | nM | - |
| CHEMBL325864 | SCOPARONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL256915 | CLEOMISCOSIN D | IC50 | > | 50000.0 | nM | - |
| CHEMBL404050 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 204080.0 | nM | - |
| CHEMBL256497 | EDULITINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL255298 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL402069 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL509839 | ISODICTAMNINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL22533 | DICTAMNINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL254379 | LUVANGETIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL71851 | SCOPOLETIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL438883 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL256536 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL255299 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL274512 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL403946 | — | IC50 | > | 50000.0 | nM | - |