Assay Detail
ADMET
CHEMBL937498
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Inhibition of CYP3A4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260636 | — | — | 1 | 9.00 |
| CHEMBL405895 | — | — | 1 | 9.00 |
| CHEMBL261288 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260636 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL405895 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL261288 | — | IC50 | = | 4300.0 | nM | 5.37 |