Assay Detail
Binding
CHEMBL938411
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Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macacine alphaherpesvirus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.29 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | 6.82 |
| CHEMBL441732 | — | — | 1 | 5.92 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.82 |
| CHEMBL1129 | TRIFLURIDINE | 4.0 | 1 | 5.70 |
| CHEMBL408518 | — | — | 1 | 5.70 |
| CHEMBL405761 | — | — | 1 | 5.46 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 5.39 |
| CHEMBL221982 | — | — | 1 | 5.38 |
| CHEMBL406254 | — | — | 1 | 4.94 |
| CHEMBL261850 | — | — | 1 | 4.82 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 4.49 |
| CHEMBL261325 | — | — | 1 | 4.28 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 4.07 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
| CHEMBL258513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318153 | EDOXUDINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL441732 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL788 | IDOXURIDINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1129 | TRIFLURIDINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL408518 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL405761 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL52609 | DOXRIBTIMINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL221982 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL406254 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL261850 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL31634 | BRIVUDINE | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL261325 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL1540 | PENCICLOVIR | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 800000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 1000000.0 | nM | - |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 900000.0 | nM | - |
| CHEMBL258513 | — | IC50 | = | 177000.0 | nM | - |