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Assay Detail

CHEMBL938649

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Half life in mouse brain
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Tissue Brain
Confidence 1 — Organism
Curated By Autocuration

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
Seierstad M, Breitenbucher JG.
J Med Chem (2008) 51 : 7327 -7343
PubMed 18983142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
T1/2 6 - -
IC50 5 5.71 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL457882 1 6.16
CHEMBL213092 1 6.16
CHEMBL456238 1 5.40
CHEMBL377268 1 5.10
CHEMBL190503 PHENYLMETHYLSULFONYLFLUORIDE 1 -
CHEMBL462987 1 -
CHEMBL446277 1 -
CHEMBL462986 1 -
CHEMBL113262 METHOXYARACHIDONOYL FLUOROPHOSPHONATE 1 -
CHEMBL184238 URB-597 1.0 1 -
CHEMBL458944 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL457882 IC50 = 690.0 nM 6.16
CHEMBL213092 IC50 = 690.0 nM 6.16
CHEMBL456238 IC50 = 4000.0 nM 5.40
CHEMBL377268 IC50 = 8000.0 nM 5.10
CHEMBL190503 PHENYLMETHYLSULFONYLFLUORIDE T1/2 = 52.0 hr -
CHEMBL462987 T1/2 = 52.0 hr -
CHEMBL446277 T1/2 = 52.0 hr -
CHEMBL462986 T1/2 = 52.0 hr -
CHEMBL113262 METHOXYARACHIDONOYL FLUOROPHOSPHONATE T1/2 = 52.0 hr -
CHEMBL184238 URB-597 T1/2 = 52.0 hr -
CHEMBL458944 IC50 < 1000.0 nM -