Assay Detail
Functional
CHEMBL938865
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Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three new triterpenes from the seeds of Combretum quadrangulare and their hepatoprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.31 | 4.52 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 4.52 |
| CHEMBL472852 | — | — | 1 | 4.29 |
| CHEMBL516291 | — | — | 1 | 4.29 |
| CHEMBL464466 | ARJUNOLIC ACID | — | 1 | 4.23 |
| CHEMBL515706 | — | — | 1 | 4.21 |
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | - |
| CHEMBL502086 | QUADRANOSIDE II | — | 1 | - |
| CHEMBL510768 | QUADRANOSIDE I | — | 1 | - |
| CHEMBL515920 | — | — | 1 | - |
| CHEMBL500352 | QUADRANOSIDE IV | — | 1 | - |
| CHEMBL449365 | NIGAICHIGOSIDE F1 | — | 1 | - |
| CHEMBL500700 | QUADRANOSIDE V | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9509 | SILIBININ | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL472852 | — | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL516291 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL464466 | ARJUNOLIC ACID | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL515706 | — | IC50 | = | 60900.0 | nM | 4.21 |
| CHEMBL441687 | GLYCYRRHIZIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL502086 | QUADRANOSIDE II | Activity | - | — | - | |
| CHEMBL510768 | QUADRANOSIDE I | Activity | - | — | - | |
| CHEMBL515920 | — | Activity | - | — | - | |
| CHEMBL500352 | QUADRANOSIDE IV | Activity | - | — | - | |
| CHEMBL449365 | NIGAICHIGOSIDE F1 | Activity | - | — | - | |
| CHEMBL500700 | QUADRANOSIDE V | Activity | - | — | - |