Assay Detail
Binding
CHEMBL938975
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Inhibition of Cryptococcus neoformans recombinant Carbonic anhydrase 2 pre-incubated for 15 mins by CO2 hydration stopped-flow assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptococcus neoformans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.54 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL453758 | — | — | 1 | 5.07 |
| CHEMBL140780 | TOLYL BORONIC ACID | — | 1 | 5.05 |
| CHEMBL20866 | — | — | 1 | 5.02 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | — | 1 | 5.00 |
| CHEMBL555064 | — | — | 1 | 4.96 |
| CHEMBL141079 | — | — | 1 | 4.96 |
| CHEMBL459151 | — | — | 1 | 4.94 |
| CHEMBL21427 | — | — | 1 | 4.94 |
| CHEMBL559289 | STYRYLBORONIC ACID | — | 1 | - |
| CHEMBL551649 | — | — | 1 | - |
| CHEMBL561852 | — | — | 1 | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | — | 1 | - |
| CHEMBL539140 | — | — | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL453758 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL140780 | TOLYL BORONIC ACID | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL20866 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL555064 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL141079 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL459151 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL21427 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL559289 | STYRYLBORONIC ACID | Ki | = | 490000.0 | nM | - |
| CHEMBL551649 | — | Ki | = | 521000.0 | nM | - |
| CHEMBL561852 | — | Ki | = | 3040000.0 | nM | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | Ki | = | 428000.0 | nM | - |
| CHEMBL539140 | — | Ki | = | 506000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 810000.0 | nM | - |