Compound Detail
CHEMBL559289
STYRYLBORONIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL559289 |
| Name | STYRYLBORONIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKIJXFIYBAYHOE-VOTSOKGWSA-N |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
148.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 4.9
IC50 1 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SH-SY5Y CHEMBL614910 | IC50 | 5.09 | 5.09 | 8080.0 | 1 |
| Carbonic anhydrase 1 CHEMBL261 | Ki | 4.9 | 4.9 | 12500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SH-SY5Y | IC50 | = | 8080.0 | nM | 5.09 | Neuroprotective activity in human APP695-transfected SH-SY5Y cells assessed as i... | 23219701 |
| Carbonic anhydrase 1 | Ki | = | 12500.0 | nM | 4.9 | Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for ... | 19375309 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23219701 | 10.1016/j.bmcl.2012.11.068 | SH-SY5Y | 8 |
| 23219701 | 10.1016/j.bmcl.2012.11.068 | Amyloid-beta precursor protein | 2 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase 1 | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase 2 | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Unchecked | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase | 1 |
| 23219701 | 10.1016/j.bmcl.2012.11.068 | ADMET | 1 |
| 23219701 | 10.1016/j.bmcl.2012.11.068 | Acetylcholinesterase | 1 |
Data from ChEMBL 36 via Core Engine