Compound Detail
CHEMBL485742
BIPHENYLBORONIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL485742 |
| Name | BIPHENYLBORONIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XPEIJWZLPWNNOK-UHFFFAOYSA-N |
6
Targets
7
Activities
2
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
198.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 5.43
IC50 3 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 7.68 | 6.89 | 21.0 | 2 |
| Carbonic anhydrase 1 CHEMBL261 | Ki | 5.43 | 5.43 | 3700.0 | 1 |
| Carbonic anhydrase 2 CHEMBL205 | Ki | 5.35 | 5.35 | 4500.0 | 1 |
| Carbonic anhydrase CHEMBL5337 | Ki | 5.11 | 5.11 | 7800.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.0 | 5.0 | 9900.0 | 1 |
| Monoglyceride lipase CHEMBL4191 | IC50 | 4.72 | 4.72 | 19000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 21.0 | nM | 7.68 | Inhibition of Wistar rat brain FAAH assessed as [3H]arachidonoylethanolamide hyd... | 18983140 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 790.0 | nM | 6.1 | Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanola... | 26850005 |
| Carbonic anhydrase 1 | Ki | = | 3700.0 | nM | 5.43 | Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for ... | 19375309 |
| Carbonic anhydrase 2 | Ki | = | 4500.0 | nM | 5.35 | Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for ... | 19375309 |
| Carbonic anhydrase | Ki | = | 7800.0 | nM | 5.11 | Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for ... | 19375309 |
| Unchecked | Ki | = | 9900.0 | nM | 5.0 | Inhibition of Cryptococcus neoformans recombinant Carbonic anhydrase 2 pre-incub... | 19375309 |
| Monoglyceride lipase | IC50 | = | 19000.0 | nM | 4.72 | Inhibition of human recombinant MGL | 18983140 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26850005 | 10.1016/j.bmcl.2016.01.071 | Transient receptor potential cation channel subfamily V member 1 | 3 |
| 19731939 | 10.1021/jm9009718 | Penicillin-binding protein 2X | 2 |
| 18983140 | 10.1021/jm801051t | Fatty-acid amide hydrolase 1 | 1 |
| 18983140 | 10.1021/jm801051t | Monoglyceride lipase | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase 1 | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase 2 | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Unchecked | 1 |
| 19375309 | 10.1016/j.bmcl.2009.03.147 | Carbonic anhydrase | 1 |
| 19731939 | 10.1021/jm9009718 | D-alanyl-D-alanine carboxypeptidase | 1 |
| 19731939 | 10.1021/jm9009718 | No relevant target | 1 |
| 26850005 | 10.1016/j.bmcl.2016.01.071 | Fatty-acid amide hydrolase 1 | 1 |
| 35792385 | 10.1016/j.ejmech.2022.114571 | Escherichia coli | 1 |
Data from ChEMBL 36 via Core Engine