Assay Detail
Binding
CHEMBL950887
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Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.64 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | — | 1 | 5.35 |
| CHEMBL141079 | — | — | 1 | 5.22 |
| CHEMBL20866 | — | — | 1 | 5.16 |
| CHEMBL21427 | — | — | 1 | 5.10 |
| CHEMBL555064 | — | — | 1 | 5.06 |
| CHEMBL140780 | TOLYL BORONIC ACID | — | 1 | 4.97 |
| CHEMBL459151 | — | — | 1 | 4.94 |
| CHEMBL20461 | PHENETHYLBORONIC ACID | — | 1 | 4.75 |
| CHEMBL539140 | — | — | 1 | 4.74 |
| CHEMBL561852 | — | — | 1 | 4.56 |
| CHEMBL551649 | — | — | 1 | - |
| CHEMBL453758 | — | — | 1 | - |
| CHEMBL559289 | STYRYLBORONIC ACID | — | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL141079 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL20866 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL21427 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL555064 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL140780 | TOLYL BORONIC ACID | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL459151 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL20461 | PHENETHYLBORONIC ACID | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL539140 | — | Ki | = | 18100.0 | nM | 4.74 |
| CHEMBL561852 | — | Ki | = | 27600.0 | nM | 4.56 |
| CHEMBL551649 | — | Ki | = | 617000.0 | nM | - |
| CHEMBL453758 | — | Ki | = | 373000.0 | nM | - |
| CHEMBL559289 | STYRYLBORONIC ACID | Ki | = | 534000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 1050000.0 | nM | - |