Assay Detail
Binding
CHEMBL939895
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Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Carbonic anhydrase (CHEMBL5337) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.29 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.88 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.04 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 5.97 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | — | 1 | 5.11 |
| CHEMBL555064 | — | — | 1 | 5.10 |
| CHEMBL459151 | — | — | 1 | 5.07 |
| CHEMBL140780 | TOLYL BORONIC ACID | — | 1 | 5.05 |
| CHEMBL141079 | — | — | 1 | 5.03 |
| CHEMBL21427 | — | — | 1 | 4.81 |
| CHEMBL20866 | — | — | 1 | 4.80 |
| CHEMBL453758 | — | — | 1 | 4.37 |
| CHEMBL559289 | STYRYLBORONIC ACID | — | 1 | - |
| CHEMBL551649 | — | — | 1 | - |
| CHEMBL561852 | — | — | 1 | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | — | 1 | - |
| CHEMBL539140 | — | — | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL485742 | BIPHENYLBORONIC ACID | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL555064 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL459151 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL140780 | TOLYL BORONIC ACID | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL141079 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL21427 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL20866 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL453758 | — | Ki | = | 42300.0 | nM | 4.37 |
| CHEMBL559289 | STYRYLBORONIC ACID | Ki | = | 779000.0 | nM | - |
| CHEMBL551649 | — | Ki | = | 460000.0 | nM | - |
| CHEMBL561852 | — | Ki | = | 5210000.0 | nM | - |
| CHEMBL20461 | PHENETHYLBORONIC ACID | Ki | = | 412000.0 | nM | - |
| CHEMBL539140 | — | Ki | = | 633000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 30850000.0 | nM | - |