Assay Detail
Binding
CHEMBL940137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-HSD1 expressed in intact human T47D cells after 30 mins
36
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 22 | - | - |
| IC50 | 14 | 5.53 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407968 | — | — | 1 | 7.57 |
| CHEMBL408487 | — | — | 1 | 5.77 |
| CHEMBL410224 | — | — | 1 | 5.75 |
| CHEMBL259000 | — | — | 1 | 5.70 |
| CHEMBL408485 | — | — | 1 | 5.54 |
| CHEMBL261578 | — | — | 1 | 5.43 |
| CHEMBL260518 | — | — | 1 | 5.43 |
| CHEMBL408594 | — | — | 1 | 5.43 |
| CHEMBL260227 | — | — | 1 | 5.33 |
| CHEMBL260234 | — | — | 1 | 5.32 |
| CHEMBL260075 | — | — | 1 | 5.27 |
| CHEMBL259815 | — | — | 1 | 5.08 |
| CHEMBL407865 | — | — | 1 | 5.00 |
| CHEMBL259814 | — | — | 1 | 4.81 |
| CHEMBL260590 | — | — | 1 | - |
| CHEMBL260802 | — | — | 1 | - |
| CHEMBL258783 | — | — | 1 | - |
| CHEMBL427905 | — | — | 1 | - |
| CHEMBL258784 | — | — | 1 | - |
| CHEMBL261157 | — | — | 1 | - |
| CHEMBL261158 | — | — | 1 | - |
| CHEMBL260710 | — | — | 1 | - |
| CHEMBL261335 | — | — | 1 | - |
| CHEMBL406542 | — | — | 1 | - |
| CHEMBL260512 | — | — | 1 | - |
| CHEMBL259205 | — | — | 1 | - |
| CHEMBL259204 | — | — | 1 | - |
| CHEMBL259203 | — | — | 1 | - |
| CHEMBL259817 | — | — | 1 | - |
| CHEMBL261844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407968 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL408487 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL410224 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL259000 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL408485 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL261578 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL260518 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL408594 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL260227 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL260234 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL260075 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL259815 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL407865 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL259814 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL261576 | — | Inhibition | - | % | - | |
| CHEMBL261843 | — | Inhibition | - | % | - | |
| CHEMBL261842 | — | Inhibition | - | % | - | |
| CHEMBL261740 | — | Inhibition | - | % | - | |
| CHEMBL259228 | — | Inhibition | - | % | - | |
| CHEMBL260589 | — | Inhibition | - | % | - | |
| CHEMBL260590 | — | Inhibition | - | % | - | |
| CHEMBL260802 | — | Inhibition | - | % | - | |
| CHEMBL258783 | — | Inhibition | - | % | - | |
| CHEMBL427905 | — | Inhibition | - | % | - | |
| CHEMBL258784 | — | Inhibition | - | % | - | |
| CHEMBL261157 | — | Inhibition | - | % | - | |
| CHEMBL261158 | — | Inhibition | - | % | - | |
| CHEMBL260710 | — | Inhibition | - | % | - | |
| CHEMBL261335 | — | Inhibition | - | % | - | |
| CHEMBL406542 | — | Inhibition | - | % | - | |
| CHEMBL260512 | — | Inhibition | - | % | - | |
| CHEMBL259205 | — | Inhibition | - | % | - | |
| CHEMBL259204 | — | Inhibition | - | % | - | |
| CHEMBL259203 | — | Inhibition | - | % | - | |
| CHEMBL259817 | — | Inhibition | - | % | - | |
| CHEMBL261844 | — | Inhibition | - | % | - |