Assay Detail
Binding
CHEMBL940856
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Displacement of [3H]mepyramine from H1R in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.45 | 8.05 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL716 | QUETIAPINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL708 | ZIPRASIDONE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1112 | ARIPIPRAZOLE | IC50 | > | 3000.0 | nM | - |
| CHEMBL54 | HALOPERIDOL | IC50 | > | 2000.0 | nM | - |