Assay Detail
ADMET
CHEMBL940927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]bufuralol from CYP2D6
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.23 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401406 | — | — | 1 | 5.46 |
| CHEMBL247838 | — | — | 1 | 5.41 |
| CHEMBL246633 | — | — | 1 | 5.08 |
| CHEMBL246634 | — | — | 1 | 4.96 |
| CHEMBL17350 | TRAXOPRODIL | 2.0 | 1 | - |
| CHEMBL247837 | — | — | 1 | - |
| CHEMBL247839 | — | — | 1 | - |
| CHEMBL401407 | — | — | 1 | - |
| CHEMBL404851 | — | — | 1 | - |
| CHEMBL246816 | — | — | 1 | - |
| CHEMBL246815 | — | — | 1 | - |
| CHEMBL246635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401406 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL247838 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL246633 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL246634 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | > | 10000.0 | nM | - |
| CHEMBL247837 | — | IC50 | < | 300.0 | nM | - |
| CHEMBL247839 | — | IC50 | - | — | - | |
| CHEMBL401407 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL404851 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL246816 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL246815 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL246635 | — | IC50 | > | 30000.0 | nM | - |