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Assay Detail

CHEMBL941605

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ADMET
Cytotoxicity against rat L6 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ.
Antimicrob Agents Chemother (2007) 51 : 3796 -3802
PubMed 17698622 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.44 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416956 MEFLOQUINE 4.0 1 5.32
CHEMBL479200 1 4.88
CHEMBL518446 1 4.44
CHEMBL478525 1 4.32
CHEMBL478371 1 4.29
CHEMBL478289 1 4.29
CHEMBL477288 1 4.27
CHEMBL479195 1 4.10
CHEMBL515337 1 4.01
CHEMBL514009 1 -
CHEMBL516107 1 -
CHEMBL515019 1 -
CHEMBL500770 1 -
CHEMBL445822 1 -
CHEMBL477500 1 -
CHEMBL474280 1 -
CHEMBL502204 1 -
CHEMBL515650 1 -
CHEMBL478367 1 -
CHEMBL478541 1 -
CHEMBL478542 1 -
CHEMBL475085 1 -
CHEMBL478153 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416956 MEFLOQUINE IC50 = 4760.0 nM 5.32
CHEMBL479200 IC50 = 13200.0 nM 4.88
CHEMBL518446 IC50 = 36300.0 nM 4.44
CHEMBL478525 IC50 = 48400.0 nM 4.32
CHEMBL478371 IC50 = 51600.0 nM 4.29
CHEMBL478289 IC50 = 51700.0 nM 4.29
CHEMBL477288 IC50 = 53800.0 nM 4.27
CHEMBL479195 IC50 = 78800.0 nM 4.10
CHEMBL515337 IC50 = 97300.0 nM 4.01
CHEMBL514009 IC50 - -
CHEMBL516107 IC50 - -
CHEMBL515019 IC50 - -
CHEMBL500770 IC50 - -
CHEMBL445822 IC50 - -
CHEMBL477500 IC50 - -
CHEMBL474280 IC50 - -
CHEMBL502204 IC50 - -
CHEMBL515650 IC50 - -
CHEMBL478367 IC50 - -
CHEMBL478541 IC50 > 200000.0 nM -
CHEMBL478542 IC50 > 200000.0 nM -
CHEMBL475085 IC50 - -
CHEMBL478153 IC50 - -