Assay Detail
Functional
CHEMBL941721
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Induction of mouse BaF3 cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrimidine benzamide-based thrombopoietin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.96 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429295 | — | — | 1 | 6.54 |
| CHEMBL248218 | — | — | 1 | 6.47 |
| CHEMBL248217 | — | — | 1 | 6.15 |
| CHEMBL249471 | — | — | 1 | 6.00 |
| CHEMBL248390 | — | — | 1 | 5.96 |
| CHEMBL245795 | — | — | 1 | 5.89 |
| CHEMBL428226 | — | — | 1 | 5.85 |
| CHEMBL442278 | — | — | 1 | 5.85 |
| CHEMBL248389 | — | — | 1 | 5.80 |
| CHEMBL247017 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429295 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL248218 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL248217 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL249471 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL248390 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL245795 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL428226 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL442278 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL248389 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL247017 | — | EC50 | = | 8500.0 | nM | 5.07 |