Compound Detail
CHEMBL245795
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Basic Information
| ChEMBL ID | CHEMBL245795 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KCOHHLPXBXNCIJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
483.5
MW (Da)
5.55
ALogP
7
HBA
2
HBD
89.0
PSA (Ų)
0.40
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 7.57 | 7.57 | 27.0 | 1 |
| BaF3 CHEMBL614524 | EC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 27.0 | nM | 7.57 | Agonist activity at human TPOr expressed in BaF3 cells by reporter assay | 17707640 |
| BaF3 | EC50 | = | 1300.0 | nM | 5.89 | Induction of mouse BaF3 cell proliferation | 17707640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17707640 | 10.1016/j.bmcl.2007.07.038 | Thrombopoietin receptor | 1 |
| 17707640 | 10.1016/j.bmcl.2007.07.038 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine