Assay Detail
Functional
CHEMBL941729
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Cytotoxicity against mouse P388 cells after 48 hrs by tetrazolium-formazan method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly efficient antitumor agents of heterocycles containing sulfur atom: linear and angular thiazonaphthalimides against human lung cancer cell in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.07 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179856 | — | — | 1 | 8.30 |
| CHEMBL391424 | — | — | 1 | 8.08 |
| CHEMBL240244 | — | — | 1 | 7.73 |
| CHEMBL240243 | — | — | 1 | 7.28 |
| CHEMBL239615 | — | — | 1 | 7.08 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.70 |
| CHEMBL181783 | — | — | 1 | 6.53 |
| CHEMBL179971 | — | — | 1 | 5.99 |
| CHEMBL179855 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179856 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL391424 | — | IC50 | = | 8.31 | nM | 8.08 |
| CHEMBL240244 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL240243 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL239615 | — | IC50 | = | 83.9 | nM | 7.08 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL181783 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL179971 | — | IC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL179855 | — | IC50 | = | 1227.0 | nM | 5.91 |