Assay Detail
Functional
CHEMBL944055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells after 72 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.02 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399492 | — | — | 1 | 7.00 |
| CHEMBL253545 | — | — | 1 | 6.70 |
| CHEMBL253768 | — | — | 1 | 6.10 |
| CHEMBL225519 | — | — | 1 | 5.96 |
| CHEMBL402272 | — | — | 1 | 5.77 |
| CHEMBL250693 | — | — | 1 | 5.33 |
| CHEMBL1203954 | — | — | 1 | 5.26 |
| CHEMBL254597 | — | — | 1 | - |
| CHEMBL253760 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399492 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL253545 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL253768 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL225519 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL402272 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL250693 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1203954 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL254597 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL253760 | — | IC50 | > | 10000.0 | nM | - |