Assay Detail
Functional
CHEMBL944953
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Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.99 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428240 | — | — | 1 | 8.70 |
| CHEMBL399124 | — | — | 1 | 8.70 |
| CHEMBL252565 | — | — | 1 | 8.52 |
| CHEMBL398341 | — | — | 1 | 8.52 |
| CHEMBL254236 | — | — | 1 | 8.52 |
| CHEMBL399295 | — | — | 1 | 8.40 |
| CHEMBL399294 | — | — | 1 | 8.40 |
| CHEMBL229110 | — | — | 1 | 8.30 |
| CHEMBL254654 | — | — | 1 | 8.30 |
| CHEMBL254862 | — | — | 1 | 8.22 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.05 |
| CHEMBL228768 | — | — | 1 | 7.80 |
| CHEMBL254653 | — | — | 1 | 7.77 |
| CHEMBL196832 | — | — | 1 | 7.72 |
| CHEMBL439196 | — | — | 1 | 7.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.44 |
| CHEMBL401119 | — | — | 1 | 7.41 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.37 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.37 |
| CHEMBL254446 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428240 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL399124 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL252565 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL398341 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL254236 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL399295 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL399294 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL229110 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL254654 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL254862 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL107 | COLCHICINE | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL228768 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL254653 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL196832 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL439196 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL428647 | PACLITAXEL | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL401119 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL159 | VINBLASTINE | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL90555 | VINCRISTINE | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL254446 | — | EC50 | = | 150.0 | nM | 6.82 |