Assay Detail
ADMET
CHEMBL945013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.59 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403977 | — | — | 1 | 6.96 |
| CHEMBL372575 | — | — | 1 | 6.70 |
| CHEMBL252469 | — | — | 1 | 6.24 |
| CHEMBL254518 | — | — | 1 | 6.20 |
| CHEMBL402953 | — | — | 1 | 6.14 |
| CHEMBL252490 | — | — | 1 | 5.82 |
| CHEMBL403744 | — | — | 1 | 5.80 |
| CHEMBL251882 | — | — | 1 | 5.80 |
| CHEMBL253083 | — | — | 2 | 5.77 |
| CHEMBL252089 | — | — | 1 | 5.54 |
| CHEMBL403065 | — | — | 1 | 5.40 |
| CHEMBL252886 | — | — | 1 | 5.14 |
| CHEMBL252887 | — | — | 1 | 5.01 |
| CHEMBL436847 | — | — | 1 | 4.82 |
| CHEMBL253082 | — | — | 1 | 4.82 |
| CHEMBL252090 | — | — | 1 | 4.58 |
| CHEMBL251883 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403977 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL372575 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL252469 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL254518 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL402953 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL252490 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL403744 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL251882 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL253083 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL252089 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL253083 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL403065 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL252886 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL252887 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL436847 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL253082 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL252090 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL251883 | — | IC50 | = | 36000.0 | nM | 4.44 |