Assay Detail
Binding
CHEMBL945309
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Inhibition of SYK
24
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.43 | 8.40 |
| IC50 | 3 | 7.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511670 | — | — | 1 | 8.40 |
| CHEMBL471424 | — | — | 1 | 8.30 |
| CHEMBL509161 | — | — | 1 | 8.10 |
| CHEMBL512345 | — | — | 1 | 8.10 |
| CHEMBL512172 | — | — | 1 | 8.05 |
| CHEMBL485731 | — | — | 1 | 8.00 |
| CHEMBL511811 | — | — | 1 | 8.00 |
| CHEMBL472478 | — | — | 1 | 7.85 |
| CHEMBL475249 | — | — | 1 | 7.66 |
| CHEMBL451450 | — | — | 1 | 7.64 |
| CHEMBL470780 | — | — | 1 | 7.64 |
| CHEMBL475254 | — | — | 1 | 7.58 |
| CHEMBL512319 | — | — | 1 | 7.55 |
| CHEMBL471727 | — | — | 1 | 7.50 |
| CHEMBL486751 | — | — | 1 | 7.48 |
| CHEMBL471901 | — | — | 1 | 7.39 |
| CHEMBL470175 | — | — | 1 | 7.36 |
| CHEMBL485730 | — | — | 1 | 7.30 |
| CHEMBL453217 | — | — | 1 | 7.25 |
| CHEMBL471819 | — | — | 1 | 7.09 |
| CHEMBL471776 | — | — | 1 | 6.96 |
| CHEMBL473229 | — | — | 1 | 6.68 |
| CHEMBL513985 | — | — | 1 | 6.20 |
| CHEMBL475570 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511670 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL471424 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL509161 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL512345 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL512172 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL485731 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL511811 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL472478 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL475249 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL451450 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL470780 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL475254 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL512319 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL471727 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL486751 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL471901 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL470175 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL485730 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL453217 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL471819 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL471776 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL473229 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL513985 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL475570 | — | Ki | = | 1817.0 | nM | 5.74 |