Compound Detail
CHEMBL513985
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Basic Information
| ChEMBL ID | CHEMBL513985 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JDMSPHKFVGVCKN-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
5.14
ALogP
6
HBA
1
HBD
59.9
PSA (Ų)
0.54
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Ki 1 meas. best 6.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | Ki | 6.2 | 6.2 | 630.0 | 1 |
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | Ki | = | 630.0 | nM | 6.2 | Inhibition of SYK | 18938080 |
| Tyrosine-protein kinase SYK | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of recombinant Syk | 19254842 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18938080 | 10.1016/j.bmcl.2008.09.106 | Tyrosine-protein kinase SYK | 1 |
| 19254842 | 10.1016/j.bmcl.2009.02.049 | Tyrosine-protein kinase SYK | 1 |
Data from ChEMBL 36 via Core Engine