Assay Detail
Binding
CHEMBL945890
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Inhibition of human AchE
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Multi-target-directed ligands to combat neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.12 | 10.70 |
| Ki | 1 | 8.59 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225567 | — | — | 1 | 10.70 |
| CHEMBL225198 | — | — | 1 | 10.22 |
| CHEMBL194823 | LIPOCRINE | — | 1 | 9.60 |
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 9.52 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | 9.00 |
| CHEMBL179455 | — | — | 1 | 8.81 |
| CHEMBL231160 | MEMOQUIN | — | 1 | 8.59 |
| CHEMBL15056 | — | — | 1 | 8.59 |
| CHEMBL254016 | — | — | 1 | 8.48 |
| CHEMBL195241 | — | — | 1 | 8.39 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.64 |
| CHEMBL403260 | — | — | 1 | 7.44 |
| CHEMBL75121 | — | — | 1 | 7.35 |
| CHEMBL374184 | — | — | 1 | 7.35 |
| CHEMBL158946 | — | — | 1 | 7.22 |
| CHEMBL194372 | — | — | 1 | 7.00 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.77 |
| CHEMBL32329 | — | — | 1 | 6.75 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.38 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 6.04 |
| CHEMBL257540 | — | — | 1 | 6.02 |
| CHEMBL364545 | — | — | 1 | 5.56 |
| CHEMBL356385 | — | — | 1 | 5.51 |
| CHEMBL109018 | — | — | 1 | 5.47 |
| CHEMBL590603 | — | — | 1 | 5.22 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 5.14 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.49 |
| CHEMBL255230 | — | — | 1 | 4.36 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.28 |
| CHEMBL199585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225567 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL225198 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL194823 | LIPOCRINE | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL134342 | THIOCTIC ACID | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL179455 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL231160 | MEMOQUIN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL15056 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL254016 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL195241 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL403260 | — | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL75121 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL374184 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL158946 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL194372 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL32329 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL95 | TACRINE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL257540 | — | IC50 | = | 952.0 | nM | 6.02 |
| CHEMBL364545 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL356385 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL109018 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL590603 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL255230 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL199585 | — | IC50 | = | 0.008 | nM | - |
| CHEMBL41 | FLUOXETINE | IC50 | > | 10000.0 | nM | - |