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Compound Detail

CHEMBL32329

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Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL32329
Phase Preclinical
Structure Type MOL
InChI Key QLRUDVGUKJOCFW-PCLIKHOPSA-N
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

400.3
MW (Da)
5.46
ALogP
2
HBA
0
HBD
25.5
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H21Cl2N2O+
MW 400.33
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -0.78

Activity Summary

EC50 1 meas. best 5.03
IC50 1 meas. best 6.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 6.75 6.75 180.0 1
Muscarinic acetylcholine receptor M2
CHEMBL4781
EC50 5.03 5.03 9400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8182702 10.1021/jm00036a008 Muscarinic acetylcholine receptor M2 2
8182702 10.1021/jm00036a008 No relevant target 1
18181565 10.1021/jm7009364 Acetylcholinesterase 1
18181565 10.1021/jm7009364 Unchecked 1

Data from ChEMBL 36 via Core Engine