Assay Detail
Binding
CHEMBL945896
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Inhibition of SERT
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multi-target-directed ligands to combat neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.07 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194372 | — | — | 1 | 7.38 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.75 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194372 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL636 | RIVASTIGMINE | IC50 | > | 1000.0 | nM | - |