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Assay Detail

CHEMBL945945

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Binding
Inhibition of wild type HIV reverse transcriptase
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
Mackman RL, Boojamra CG, Prasad V, Zhang L, Lin KY, Petrakovsky O, Babusis D, Chen J, Douglas J, Grant D, Hui HC, Kim CU, Markevitch DY, Vela J, Ray A, Cihlar T.
Bioorg Med Chem Lett (2007) 17 : 6785 -6789
PubMed 18029175 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.18 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL412300 1 7.22
CHEMBL270776 1 6.92
CHEMBL1380 ABACAVIR 4.0 1 6.89
CHEMBL270066 1 6.85
CHEMBL412310 1 6.58
CHEMBL270914 1 6.50
CHEMBL483 TENOFOVIR ANHYDROUS 3.0 1 6.42
CHEMBL122885 1 6.41
CHEMBL269858 1 6.26
CHEMBL420843 1 6.22
CHEMBL272231 2 6.08
CHEMBL405822 1 5.39
CHEMBL229111 1 5.27
CHEMBL437070 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL412300 IC50 = 60.0 nM 7.22
CHEMBL270776 IC50 = 120.0 nM 6.92
CHEMBL1380 ABACAVIR IC50 = 130.0 nM 6.89
CHEMBL270066 IC50 = 140.0 nM 6.85
CHEMBL412310 IC50 = 260.0 nM 6.58
CHEMBL270914 IC50 = 320.0 nM 6.50
CHEMBL483 TENOFOVIR ANHYDROUS IC50 = 380.0 nM 6.42
CHEMBL122885 IC50 = 390.0 nM 6.41
CHEMBL269858 IC50 = 550.0 nM 6.26
CHEMBL420843 IC50 = 600.0 nM 6.22
CHEMBL272231 IC50 = 830.0 nM 6.08
CHEMBL405822 IC50 = 4100.0 nM 5.39
CHEMBL229111 IC50 = 5400.0 nM 5.27
CHEMBL437070 IC50 = 5700.0 nM 5.24
CHEMBL272231 IC50 = 31000.0 nM 4.51