Compound Detail
CHEMBL270914
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Basic Information
| ChEMBL ID | CHEMBL270914 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTAFNACSIFHWHY-RQJHMYQMSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
315.2
MW (Da)
-0.15
ALogP
8
HBA
3
HBD
145.6
PSA (Ų)
0.66
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.02
IC50 1 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| Human immunodeficiency virus CHEMBL613758 | EC50 | 5.02 | 5.02 | 9500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 320.0 | nM | 6.5 | Inhibition of wild type HIV reverse transcriptase | 18029175 |
| Human immunodeficiency virus | EC50 | = | 9500.0 | nM | 5.02 | Antiviral activity against wild type HIV | 18029175 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18029175 | 10.1016/j.bmcl.2007.10.038 | Human immunodeficiency virus | 4 |
| 18029175 | 10.1016/j.bmcl.2007.10.038 | MT2 | 1 |
| 18029175 | 10.1016/j.bmcl.2007.10.038 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine