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Assay Detail

CHEMBL945943

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Functional
Antiviral activity against wild type HIV
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus (CHEMBL613758)
Type ORGANISM
Organism Human immunodeficiency virus

Publication

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
Mackman RL, Boojamra CG, Prasad V, Zhang L, Lin KY, Petrakovsky O, Babusis D, Chen J, Douglas J, Grant D, Hui HC, Kim CU, Markevitch DY, Vela J, Ray A, Cihlar T.
Bioorg Med Chem Lett (2007) 17 : 6785 -6789
PubMed 18029175 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 5.09 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1380 ABACAVIR 4.0 1 6.50
CHEMBL420843 1 5.68
CHEMBL483 TENOFOVIR ANHYDROUS 3.0 1 5.44
CHEMBL270914 1 5.02
CHEMBL405822 1 4.92
CHEMBL406465 1 4.82
CHEMBL122885 1 4.58
CHEMBL270705 1 4.54
CHEMBL428083 1 4.29
CHEMBL270707 1 -
CHEMBL272231 1 -
CHEMBL229111 1 -
CHEMBL270496 1 -
CHEMBL437070 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1380 ABACAVIR EC50 = 320.0 nM 6.50
CHEMBL420843 EC50 = 2100.0 nM 5.68
CHEMBL483 TENOFOVIR ANHYDROUS EC50 = 3600.0 nM 5.44
CHEMBL270914 EC50 = 9500.0 nM 5.02
CHEMBL405822 EC50 = 12000.0 nM 4.92
CHEMBL406465 EC50 = 15000.0 nM 4.82
CHEMBL122885 EC50 = 26000.0 nM 4.58
CHEMBL270705 EC50 = 28500.0 nM 4.54
CHEMBL428083 EC50 = 51700.0 nM 4.29
CHEMBL270707 EC50 > 200000.0 nM -
CHEMBL272231 EC50 > 200000.0 nM -
CHEMBL229111 EC50 > 200000.0 nM -
CHEMBL270496 EC50 > 200000.0 nM -
CHEMBL437070 EC50 > 200000.0 nM -