Assay Detail
Binding
CHEMBL947040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from human SERT expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.76 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181188 | — | — | 1 | 8.01 |
| CHEMBL272003 | — | — | 1 | 7.04 |
| CHEMBL411262 | — | — | 1 | 6.92 |
| CHEMBL223166 | — | — | 1 | 6.73 |
| CHEMBL270099 | — | — | 1 | 6.30 |
| CHEMBL272002 | — | — | 1 | 6.21 |
| CHEMBL411263 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181188 | — | Ki | = | 9.69 | nM | 8.01 |
| CHEMBL272003 | — | Ki | = | 90.88 | nM | 7.04 |
| CHEMBL411262 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL223166 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL270099 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL272002 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL411263 | — | Ki | = | 733.0 | nM | 6.13 |