Assay Detail
Functional
CHEMBL947137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Survival of human HEK293 cells after 48 hrs by MTS reduction assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.68 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270687 | MERIOLIN 5 | — | 1 | 7.07 |
| CHEMBL406463 | MERIOLIN 6 | — | 1 | 7.05 |
| CHEMBL406464 | MERIOLIN 4 | — | 1 | 6.66 |
| CHEMBL270686 | MERIOLIN 3 | — | 1 | 6.62 |
| CHEMBL270897 | MERIOLIN 2 | — | 1 | 6.02 |
| CHEMBL411704 | — | — | 1 | 5.72 |
| CHEMBL405665 | MERIOLIN 1 | — | 1 | 5.66 |
| CHEMBL271597 | — | — | 1 | 4.97 |
| CHEMBL402443 | — | — | 1 | 4.45 |
| CHEMBL270926 | — | — | 1 | 4.18 |
| CHEMBL405200 | — | — | 1 | 4.08 |
| CHEMBL271195 | — | — | 1 | - |
| CHEMBL270346 | MERIOLIN 9 | — | 1 | - |
| CHEMBL406102 | MERIOLIN 8 | — | 1 | - |
| CHEMBL405074 | MERIOLIN 7 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270687 | MERIOLIN 5 | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL406463 | MERIOLIN 6 | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL406464 | MERIOLIN 4 | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL270686 | MERIOLIN 3 | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL270897 | MERIOLIN 2 | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL411704 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL405665 | MERIOLIN 1 | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL271597 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL402443 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL270926 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL405200 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL271195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL270346 | MERIOLIN 9 | IC50 | > | 30000.0 | nM | - |
| CHEMBL406102 | MERIOLIN 8 | IC50 | > | 30000.0 | nM | - |
| CHEMBL405074 | MERIOLIN 7 | IC50 | > | 100000.0 | nM | - |