Assay Detail
Binding
CHEMBL947296
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Antiprion activity against scrapie prion protein 22L infected mouse N167 cells assessed as reduction of scrapie prion protein accumulation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | N167 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprion activity of functionalized 9-aminoacridines related to quinacrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.04 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512898 | — | — | 1 | 6.38 |
| CHEMBL472113 | — | — | 1 | 6.31 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.23 |
| CHEMBL472129 | — | — | 1 | 5.92 |
| CHEMBL511319 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512898 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL472113 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL7568 | QUINACRINE | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL472129 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL511319 | — | EC50 | = | 4290.0 | nM | 5.37 |