Assay Detail
Functional
CHEMBL947320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.28 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 8.52 |
| CHEMBL214719 | — | — | 1 | 8.22 |
| CHEMBL59030 | — | — | 1 | 7.51 |
| CHEMBL457977 | — | — | 1 | 6.26 |
| CHEMBL456237 | LXR-623 | 1.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL214719 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL59030 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL457977 | — | EC50 | = | 549.0 | nM | 6.26 |
| CHEMBL456237 | LXR-623 | EC50 | = | 1275.0 | nM | 5.89 |