Assay Detail
Binding
CHEMBL948046
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NADH-ubiquinone oxidoreductase assessed as NADH oxidase activity in bovine heart submitochondrial particles
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Iromycins from Streptomyces sp. and from synthesis: new inhibitors of the mitochondrial electron transport chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.87 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272733 | PIERICIDIN A | — | 1 | 8.30 |
| CHEMBL258096 | IROMYCIN S | — | 1 | 6.74 |
| CHEMBL270860 | IROMYCIN A | — | 1 | 6.34 |
| CHEMBL272324 | IROMYCIN M | — | 1 | 6.00 |
| CHEMBL270644 | IROMYCIN AH | — | 1 | 5.66 |
| CHEMBL270201 | IROMYCIN AM | — | 1 | 5.55 |
| CHEMBL257864 | IROMYCIN C | — | 1 | 5.45 |
| CHEMBL256862 | IROMYCIN MO | — | 1 | 5.07 |
| CHEMBL258094 | IROMYCIN SO | — | 1 | 4.82 |
| CHEMBL269802 | IROMYCIN B | — | 1 | 4.75 |
| CHEMBL272356 | IROMYCIN E | — | 1 | - |
| CHEMBL272059 | IROMYCIN F | — | 1 | - |
| CHEMBL256056 | IROMYCIN BM | — | 1 | - |
| CHEMBL256051 | IROMYCIN AA | — | 1 | - |
| CHEMBL256863 | IROMYCIN BA | — | 1 | - |
| CHEMBL258095 | IROMYCIN AO | — | 1 | - |
| CHEMBL272780 | IROMYCIN D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272733 | PIERICIDIN A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL258096 | IROMYCIN S | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL270860 | IROMYCIN A | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL272324 | IROMYCIN M | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL270644 | IROMYCIN AH | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL270201 | IROMYCIN AM | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL257864 | IROMYCIN C | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL256862 | IROMYCIN MO | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL258094 | IROMYCIN SO | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL269802 | IROMYCIN B | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL272356 | IROMYCIN E | IC50 | > | 25300.0 | nM | - |
| CHEMBL272059 | IROMYCIN F | IC50 | > | 25300.0 | nM | - |
| CHEMBL256056 | IROMYCIN BM | IC50 | > | 24300.0 | nM | - |
| CHEMBL256051 | IROMYCIN AA | IC50 | > | 23400.0 | nM | - |
| CHEMBL256863 | IROMYCIN BA | IC50 | > | 22400.0 | nM | - |
| CHEMBL258095 | IROMYCIN AO | IC50 | > | 26600.0 | nM | - |
| CHEMBL272780 | IROMYCIN D | IC50 | > | 26500.0 | nM | - |