Assay Detail
Binding
CHEMBL948348
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Displacement of [3H]paroxetine from 5HTT
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.68 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487874 | — | — | 1 | 7.84 |
| CHEMBL487875 | — | — | 1 | 7.39 |
| CHEMBL519910 | — | — | 1 | 7.37 |
| CHEMBL488423 | — | — | 1 | 7.14 |
| CHEMBL520035 | — | — | 1 | 7.10 |
| CHEMBL486042 | — | — | 1 | 7.07 |
| CHEMBL487873 | — | — | 1 | 7.05 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 7.02 |
| CHEMBL486041 | — | — | 1 | 6.95 |
| CHEMBL1790051 | — | — | 1 | 6.74 |
| CHEMBL513206 | — | — | 1 | 6.53 |
| CHEMBL469888 | — | — | 1 | 6.44 |
| CHEMBL471899 | — | — | 1 | 6.41 |
| CHEMBL470690 | — | — | 1 | 6.28 |
| CHEMBL469887 | — | — | 1 | 6.27 |
| CHEMBL511466 | — | — | 1 | 6.18 |
| CHEMBL469889 | — | — | 1 | 6.06 |
| CHEMBL512189 | — | — | 1 | 6.04 |
| CHEMBL511288 | — | — | 1 | 6.00 |
| CHEMBL470488 | — | — | 1 | 5.75 |
| CHEMBL488422 | — | — | 1 | - |
| CHEMBL471898 | — | — | 1 | - |
| CHEMBL512685 | — | — | 1 | - |
| CHEMBL471696 | — | — | 1 | - |
| CHEMBL512878 | — | — | 1 | - |
| CHEMBL470903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487874 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL487875 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL519910 | — | Ki | = | 42.9 | nM | 7.37 |
| CHEMBL488423 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL520035 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL486042 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL487873 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL486041 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL1790051 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL513206 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL469888 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL471899 | — | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL470690 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL469887 | — | Ki | = | 535.0 | nM | 6.27 |
| CHEMBL511466 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL469889 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL512189 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL511288 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL470488 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL488422 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL471898 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL512685 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL471696 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL512878 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL470903 | — | Ki | > | 2000.0 | nM | - |