Assay Detail
Binding
CHEMBL948896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]5HT uptake at human 5HT transporter expressed in HEK293 cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.71 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402057 | — | — | 1 | 8.40 |
| CHEMBL401878 | — | — | 1 | 8.30 |
| CHEMBL404258 | — | — | 1 | 8.22 |
| CHEMBL256819 | — | — | 1 | 8.22 |
| CHEMBL401819 | — | — | 1 | 8.15 |
| CHEMBL402345 | — | — | 1 | 8.10 |
| CHEMBL247733 | — | — | 1 | 8.05 |
| CHEMBL403090 | — | — | 1 | 8.00 |
| CHEMBL258062 | — | — | 1 | 7.96 |
| CHEMBL438889 | — | — | 1 | 7.92 |
| CHEMBL401877 | — | — | 1 | 7.92 |
| CHEMBL404754 | — | — | 1 | 7.89 |
| CHEMBL256818 | — | — | 1 | 7.89 |
| CHEMBL257481 | — | — | 1 | 7.89 |
| CHEMBL403441 | — | — | 1 | 7.89 |
| CHEMBL404317 | — | — | 1 | 7.85 |
| CHEMBL258060 | — | — | 1 | 7.80 |
| CHEMBL272493 | — | — | 1 | 7.77 |
| CHEMBL403071 | — | — | 1 | 7.75 |
| CHEMBL257423 | — | — | 1 | 7.75 |
| CHEMBL255957 | — | — | 1 | 7.66 |
| CHEMBL258063 | — | — | 1 | 7.55 |
| CHEMBL256817 | — | — | 1 | 7.50 |
| CHEMBL258271 | — | — | 1 | 7.43 |
| CHEMBL256816 | — | — | 1 | 7.25 |
| CHEMBL407815 | — | — | 1 | 7.14 |
| CHEMBL257424 | — | — | 1 | 6.62 |
| CHEMBL402851 | — | — | 1 | 6.55 |
| CHEMBL256058 | — | — | 1 | 6.18 |
| CHEMBL256168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402057 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL401878 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL404258 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL256819 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL401819 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL402345 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL247733 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL403090 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL258062 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL438889 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL401877 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL404754 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL256818 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL257481 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403441 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL404317 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL258060 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL272493 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL403071 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL257423 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL255957 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL258063 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL256817 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL258271 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL256816 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL407815 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL257424 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL402851 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL256058 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL256168 | — | IC50 | - | — | - |