Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL949088

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat recombinant FAAH expressed in Escherichia coli
ChEMBL ↗
118
Total Activities
95
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL.
J Med Chem (2008) 51 : 937 -947
PubMed 18247553 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 95 7.77 9.70
IC50 23 7.64 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL272111 — — 2 9.70
CHEMBL220770 — — 2 9.40
CHEMBL258820 — — 2 9.30
CHEMBL405880 — — 1 9.25
CHEMBL271745 — — 1 9.22
CHEMBL272452 — — 1 9.15
CHEMBL227046 — — 3 9.15
CHEMBL272038 — — 2 9.10
CHEMBL405604 — — 1 9.10
CHEMBL226938 — — 3 9.00
CHEMBL270929 — — 1 8.96
CHEMBL272462 — — 1 8.92
CHEMBL270487 — — 1 8.92
CHEMBL271790 — — 1 8.92
CHEMBL427424 — — 1 8.89
CHEMBL272463 — — 1 8.89
CHEMBL407061 — — 1 8.82
CHEMBL272455 — — 1 8.82
CHEMBL271390 — — 1 8.80
CHEMBL272227 — — 1 8.77
CHEMBL220729 — — 2 8.70
CHEMBL226990 — — 3 8.70
CHEMBL270720 — — 1 8.70
CHEMBL271792 — — 1 8.70
CHEMBL177577 — — 1 8.70
CHEMBL226991 — — 1 8.70
CHEMBL260746 — — 1 8.66
CHEMBL387681 — — 1 8.66
CHEMBL271530 — — 1 8.64
CHEMBL411071 — — 1 8.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL272111 — Ki = 0.2 nM 9.70
CHEMBL220770 — Ki = 0.4 nM 9.40
CHEMBL258820 — Ki = 0.5 nM 9.30
CHEMBL405880 — Ki = 0.56 nM 9.25
CHEMBL271745 — Ki = 0.6 nM 9.22
CHEMBL227046 — IC50 = 0.7 nM 9.15
CHEMBL272452 — Ki = 0.7 nM 9.15
CHEMBL227046 — Ki = 0.75 nM 9.12
CHEMBL227046 — Ki = 0.75 nM 9.12
CHEMBL272038 — Ki = 0.8 nM 9.10
CHEMBL405604 — Ki = 0.8 nM 9.10
CHEMBL272111 — IC50 = 1.0 nM 9.00
CHEMBL226938 — Ki = 1.0 nM 9.00
CHEMBL226938 — Ki = 1.0 nM 9.00
CHEMBL270929 — Ki = 1.1 nM 8.96
CHEMBL272462 — Ki = 1.2 nM 8.92
CHEMBL270487 — Ki = 1.2 nM 8.92
CHEMBL271790 — Ki = 1.2 nM 8.92
CHEMBL272463 — Ki = 1.3 nM 8.89
CHEMBL427424 — Ki = 1.3 nM 8.89
CHEMBL272455 — Ki = 1.5 nM 8.82
CHEMBL407061 — Ki = 1.5 nM 8.82
CHEMBL271390 — Ki = 1.6 nM 8.80
CHEMBL272227 — Ki = 1.7 nM 8.77
CHEMBL220729 — IC50 = 2.0 nM 8.70
CHEMBL177577 — IC50 = 2.0 nM 8.70
CHEMBL271792 — Ki = 2.0 nM 8.70
CHEMBL270720 — Ki = 2.0 nM 8.70
CHEMBL226938 — IC50 = 2.0 nM 8.70
CHEMBL226990 — IC50 = 2.0 nM 8.70
CHEMBL258820 — IC50 = 2.0 nM 8.70
CHEMBL226991 — Ki = 2.0 nM 8.70
CHEMBL260746 — Ki = 2.2 nM 8.66
CHEMBL387681 — Ki = 2.2 nM 8.66
CHEMBL271530 — Ki = 2.3 nM 8.64
CHEMBL411071 — Ki = 2.9 nM 8.54
CHEMBL270281 — Ki = 3.0 nM 8.52
CHEMBL272831 — Ki = 3.0 nM 8.52
CHEMBL279796 — Ki = 3.0 nM 8.52
CHEMBL226992 — Ki = 3.2 nM 8.49
CHEMBL226990 — Ki = 3.4 nM 8.47
CHEMBL226990 — Ki = 3.4 nM 8.47
CHEMBL269857 — Ki = 3.5 nM 8.46
CHEMBL260536 — Ki = 3.5 nM 8.46
CHEMBL405823 — Ki = 3.6 nM 8.44
CHEMBL407546 — Ki = 4.0 nM 8.40
CHEMBL272829 — Ki = 4.0 nM 8.40
CHEMBL272428 — Ki = 4.5 nM 8.35
CHEMBL260534 — Ki = 4.6 nM 8.34
CHEMBL270916 — Ki = 5.0 nM 8.30