Compound Detail
CHEMBL405604
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL405604 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JWRIESPUDCBNRV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
5.09
ALogP
4
HBA
0
HBD
52.3
PSA (Ų)
0.54
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | Ki | 9.17 | 9.17 | 0.7 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | Ki | 9.1 | 9.1 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 0.67 | nM | 9.17 | Inhibition of human recombinant FAAH expressed COS7 cells | 18247553 |
| Fatty-acid amide hydrolase 1 | Ki | = | 0.8 | nM | 9.1 | Inhibition of rat recombinant FAAH expressed in Escherichia coli | 18247553 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18247553 | 10.1021/jm701210y | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine