Assay Detail
Binding
CHEMBL949089
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Inhibition of human recombinant FAAH expressed COS7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.99 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272111 | — | — | 1 | 9.59 |
| CHEMBL258820 | — | — | 1 | 9.29 |
| CHEMBL405604 | — | — | 1 | 9.17 |
| CHEMBL272038 | — | — | 1 | 9.07 |
| CHEMBL271792 | — | — | 1 | 9.00 |
| CHEMBL270487 | — | — | 1 | 8.92 |
| CHEMBL227046 | — | — | 1 | 8.54 |
| CHEMBL226938 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272111 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL258820 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL405604 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL272038 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL271792 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL270487 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL227046 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL226938 | — | Ki | = | 5.0 | nM | 8.30 |