Assay Detail
ADMET
CHEMBL949467
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Cytotoxicity against HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.01 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488803 | — | — | 1 | 7.30 |
| CHEMBL142348 | ANDROSTENOL | — | 1 | 6.70 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | 5.52 |
| CHEMBL485938 | — | — | 1 | 5.52 |
| CHEMBL485743 | — | — | 1 | 5.52 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.52 |
| CHEMBL362919 | METHOXYCHLOR | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488803 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL142348 | ANDROSTENOL | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL691 | ETHINYL ESTRADIOL | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL485938 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL485743 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL104 | CLOTRIMAZOLE | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL362919 | METHOXYCHLOR | EC50 | > | 5000.0 | nM | - |