Assay Detail
Binding
CHEMBL950174
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Inhibition of KDR by HTRF assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.33 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429743 | — | — | 1 | 10.52 |
| CHEMBL411630 | — | — | 1 | 9.70 |
| CHEMBL270954 | — | — | 1 | 9.30 |
| CHEMBL270548 | — | — | 1 | 9.30 |
| CHEMBL409867 | — | — | 1 | 9.22 |
| CHEMBL272878 | — | — | 1 | 9.00 |
| CHEMBL270058 | — | — | 1 | 9.00 |
| CHEMBL270057 | — | — | 1 | 9.00 |
| CHEMBL429430 | — | — | 1 | 9.00 |
| CHEMBL272875 | — | — | 1 | 9.00 |
| CHEMBL270306 | — | — | 1 | 9.00 |
| CHEMBL272822 | — | — | 1 | 8.52 |
| CHEMBL270550 | — | — | 1 | 7.72 |
| CHEMBL272170 | — | — | 1 | 7.58 |
| CHEMBL270093 | — | — | 1 | 7.58 |
| CHEMBL272609 | — | — | 1 | 7.40 |
| CHEMBL270545 | — | — | 1 | 7.40 |
| CHEMBL409933 | — | — | 1 | 7.40 |
| CHEMBL272874 | — | — | 1 | 7.28 |
| CHEMBL405040 | — | — | 1 | 7.24 |
| CHEMBL272688 | — | — | 1 | 7.21 |
| CHEMBL270953 | — | — | 1 | 7.11 |
| CHEMBL271960 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429743 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL411630 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL270954 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL270548 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL409867 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL272878 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270058 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270057 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL429430 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL272875 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270306 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL272822 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL270550 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL272170 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL270093 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL272609 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL270545 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL409933 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL272874 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL405040 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL272688 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL270953 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL271960 | — | IC50 | = | 95.0 | nM | 7.02 |