Compound Detail
CHEMBL270954
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Basic Information
| ChEMBL ID | CHEMBL270954 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CEIYRBYXRSULDG-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
6
PK Parameters
7
Publications
0
Known Names
Molecular Properties
484.5
MW (Da)
4.87
ALogP
6
HBA
2
HBD
116.0
PSA (Ų)
0.42
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| HUVEC CHEMBL613979 | IC50 | 9.0 | 7.76 | 1.0 | 2 |
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 6.37 | 6.37 | 430.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 650.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 14.33 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 330.23 | nM | Rattus norvegicus |
| F | 28.0 | % | Rattus norvegicus |
| T1/2 | 1.6 | hr | Rattus norvegicus |
| Tmax | 2.3 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 0.5 | nM | 9.3 | Inhibition of KDR by HTRF assay | 18311900 |
| HUVEC | IC50 | = | 1.0 | nM | 9.0 | Inhibition of VEGF-induced proliferation of HUVEC cells | 18311900 |
| Tyrosine-protein kinase Lck | IC50 | = | 19.0 | nM | 7.72 | Inhibition of Lck | 18311900 |
| Hepatocyte growth factor receptor | IC50 | = | 260.0 | nM | 6.58 | Inhibition of c-Met | 18311900 |
| HUVEC | IC50 | = | 300.0 | nM | 6.52 | Inhibition of FGF-induced proliferation of HUVEC cells | 18311900 |
| Angiopoietin-1 receptor | IC50 | = | 430.0 | nM | 6.37 | Inhibition of Tie2 | 18311900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18311900 | 10.1021/jm701129j | Rattus norvegicus | 7 |
| 18311900 | 10.1021/jm701129j | HUVEC | 2 |
| 18311900 | 10.1021/jm701129j | Liver microsomes | 2 |
| 18311900 | 10.1021/jm701129j | Tyrosine-protein kinase Lck | 1 |
| 18311900 | 10.1021/jm701129j | Angiopoietin-1 receptor | 1 |
| 18311900 | 10.1021/jm701129j | Hepatocyte growth factor receptor | 1 |
| 18311900 | 10.1021/jm701129j | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine