Assay Detail
Binding
CHEMBL950177
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Inhibition of Tie2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.58 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270057 | — | — | 1 | 9.00 |
| CHEMBL272878 | — | — | 1 | 8.05 |
| CHEMBL270548 | — | — | 1 | 6.96 |
| CHEMBL270306 | — | — | 1 | 6.58 |
| CHEMBL409867 | — | — | 1 | 6.54 |
| CHEMBL429430 | — | — | 1 | 6.41 |
| CHEMBL270954 | — | — | 1 | 6.37 |
| CHEMBL411630 | — | — | 1 | 6.00 |
| CHEMBL272822 | — | — | 1 | 5.82 |
| CHEMBL270093 | — | — | 1 | 5.82 |
| CHEMBL270058 | — | — | 1 | 5.80 |
| CHEMBL270550 | — | — | 1 | 5.66 |
| CHEMBL405040 | — | — | 1 | - |
| CHEMBL272874 | — | — | 1 | - |
| CHEMBL270545 | — | — | 1 | - |
| CHEMBL409933 | — | — | 1 | - |
| CHEMBL272688 | — | — | 1 | - |
| CHEMBL271960 | — | — | 1 | - |
| CHEMBL272170 | — | — | 1 | - |
| CHEMBL270953 | — | — | 1 | - |
| CHEMBL272609 | — | — | 1 | - |
| CHEMBL272875 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270057 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL272878 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL270548 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL270306 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL409867 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL429430 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL270954 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL411630 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL272822 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270093 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270058 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL270550 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL405040 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL272874 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL270545 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL409933 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL272688 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL271960 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL272170 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL270953 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL272609 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL272875 | — | IC50 | > | 4000.0 | nM | - |