Compound Detail
CHEMBL271960
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Basic Information
| ChEMBL ID | CHEMBL271960 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YCNZMGUAVHXPOS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
438.9
MW (Da)
4.32
ALogP
5
HBA
2
HBD
92.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.02 | 7.02 | 95.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 95.0 | nM | 7.02 | Inhibition of KDR by HTRF assay | 18311900 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 95.5 | nM | 7.02 | Inhibition of human VEGFR2 after 60 mins | 19081278 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18311900 | 10.1021/jm701129j | HUVEC | 2 |
| 18311900 | 10.1021/jm701129j | Tyrosine-protein kinase Lck | 1 |
| 18311900 | 10.1021/jm701129j | Angiopoietin-1 receptor | 1 |
| 18311900 | 10.1021/jm701129j | Hepatocyte growth factor receptor | 1 |
| 18311900 | 10.1021/jm701129j | Vascular endothelial growth factor receptor 2 | 1 |
| 19081278 | 10.1016/j.jmgm.2008.10.006 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine