Assay Detail
Functional
CHEMBL950175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF-induced proliferation of HUVEC cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.81 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272878 | — | — | 1 | 9.40 |
| CHEMBL429430 | — | — | 1 | 9.22 |
| CHEMBL270057 | — | — | 1 | 9.22 |
| CHEMBL409867 | — | — | 1 | 9.00 |
| CHEMBL270954 | — | — | 1 | 9.00 |
| CHEMBL272822 | — | — | 1 | 8.70 |
| CHEMBL270306 | — | — | 1 | 8.52 |
| CHEMBL411630 | — | — | 1 | 8.52 |
| CHEMBL270548 | — | — | 1 | 8.40 |
| CHEMBL429743 | — | — | 1 | 8.10 |
| CHEMBL272875 | — | — | 1 | 7.64 |
| CHEMBL270058 | — | — | 1 | 7.35 |
| CHEMBL270545 | — | — | 1 | 7.28 |
| CHEMBL270550 | — | — | 1 | 7.14 |
| CHEMBL272609 | — | — | 1 | 7.00 |
| CHEMBL272170 | — | — | 1 | 6.64 |
| CHEMBL270953 | — | — | 1 | 6.64 |
| CHEMBL272874 | — | — | 1 | 6.62 |
| CHEMBL409933 | — | — | 1 | 6.60 |
| CHEMBL405040 | — | — | 1 | 6.55 |
| CHEMBL270093 | — | — | 1 | 6.44 |
| CHEMBL272688 | — | — | 1 | - |
| CHEMBL271960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272878 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL429430 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL270057 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL409867 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270954 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL272822 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL270306 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL411630 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL270548 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL429743 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL272875 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL270058 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL270545 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL270550 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL272609 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL272170 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL270953 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL272874 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL409933 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL405040 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL270093 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL272688 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL271960 | — | IC50 | > | 1000.0 | nM | - |