Assay Detail
Binding
CHEMBL950282
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Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 9.53 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409458 | — | — | 1 | 10.30 |
| CHEMBL438413 | — | — | 1 | 10.22 |
| CHEMBL272215 | — | — | 1 | 10.00 |
| CHEMBL412050 | — | — | 1 | 9.92 |
| CHEMBL410526 | — | — | 1 | 9.92 |
| CHEMBL273105 | — | — | 1 | 9.89 |
| CHEMBL410122 | — | — | 1 | 9.89 |
| CHEMBL411927 | — | — | 1 | 9.80 |
| CHEMBL429929 | — | — | 1 | 9.80 |
| CHEMBL271815 | — | — | 1 | 9.74 |
| CHEMBL407466 | — | — | 1 | 9.72 |
| CHEMBL411738 | — | — | 1 | 9.72 |
| CHEMBL410884 | — | — | 1 | 9.68 |
| CHEMBL271797 | — | — | 1 | 9.68 |
| CHEMBL271811 | — | — | 1 | 9.59 |
| CHEMBL270918 | — | — | 1 | 9.57 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.52 |
| CHEMBL260528 | — | — | 1 | 9.51 |
| CHEMBL429588 | — | — | 1 | 9.42 |
| CHEMBL272051 | — | — | 1 | 9.37 |
| CHEMBL443326 | — | — | 1 | 9.37 |
| CHEMBL409036 | — | — | 1 | 9.19 |
| CHEMBL272181 | — | — | 1 | 9.17 |
| CHEMBL271755 | — | — | 1 | 9.04 |
| CHEMBL982 | NALMEFENE | 4.0 | 1 | 9.04 |
| CHEMBL411916 | — | — | 1 | 8.92 |
| CHEMBL406116 | — | — | 1 | 8.83 |
| CHEMBL272021 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409458 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL438413 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL272215 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL412050 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL410526 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL273105 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL410122 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL411927 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL429929 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL271815 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL407466 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL411738 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL410884 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL271797 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL271811 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL270918 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL260528 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL429588 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL272051 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL443326 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL409036 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL272181 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL271755 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL982 | NALMEFENE | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL411916 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL406116 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL272021 | — | Ki | = | 10.08 | nM | 8.00 |