Assay Detail
Binding
CHEMBL950318
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Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 10.03 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270984 | — | — | 1 | 10.72 |
| CHEMBL244265 | — | — | 1 | 9.76 |
| CHEMBL269842 | — | — | 1 | 9.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270984 | — | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL244265 | — | Ki | = | 0.172 | nM | 9.76 |
| CHEMBL269842 | — | Ki | = | 0.248 | nM | 9.61 |